Glycobiology is an extension of modern molecular biology with roots in classical carbohydrate chemistry and biochemistry. The editors, in the preface to the first edition of this glycobiology textbook, believed that their work is a first of its kind. It was designed to create a textbook covering a complex and quickly evolving topic useful to both experts and novices wishing to learn more about the field.
It started with several faculty members who were teaching a graduate-level course on glycobiology at the University of California, San Diego. Add in a few new faculty members and conversations at a glycobiology conference and the table was set for the group of educators to create a basic textbook in glycobiology. Students were the initial editors, providing critiques of the text as part of their coursework.
The online glycobiology textbook has been compiled by a group of glycobiology educators and scholars under the direction of Dr. Ajit Varki and in collaboration with the National Library of Medicine/National Center for Biotechnology Information (NLM/NCBI).
Table of Contents for Essentials of Glycobiology Textbook
- Part I. General Principles
- 1. Historical Background and Overview
- 2. Structural Basis of Glycan Diversity
- 3. Cellular Organization of Glycosylation
- 4. Glycosylation Precursors
- 5. Glycosyltransferases and Glycan-processing Enzymes
- 6. Biological Roles of Glycans
- 7. A Genomic View of Glycobiology
- Part II. Structure and Biosynthesis
- 8. N-Glycans
- 9. O-GalNAc Glycans
- 10. Glycosphingolipids
- 11. Glycosylphosphatidylinositol Anchors
- 12. Other Classes of ER/Golgi-derived Glycans
- 13. Structures Common to Different Glycans
- 14. Sialic Acids
- 15. Hyaluronan
- 16. Proteoglycans and Sulfated Glycosaminoglycans
- 17. Nucleocytoplasmic Glycosylation
- 18. The O-GlcNAc Modification
- Part III. Organismal Diversity
- 19. Evolution of Glycan Diversity
- 20. Eubacteria and Archaea
- 21. Fungi
- 22. Viridiplantae
- 23. Nematoda
- 24. Arthropoda
- 25. Deuterostomes
- Part IV. Glycan-binding Proteins
- 26. Discovery and Classification of Glycan-Binding Proteins
- 27. Principles of Glycan Recognition
- 28. R-type Lectins
- 29. L-type Lectins
- 30. P-type Lectins
- 31. C-type Lectins
- 32. I-type Lectins
- 33. Galectins
- 34. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
- 35. Proteins that Bind Sulfated Glycosaminoglycans
- Part V. Glycans in Physiology and Disease
- 36. Glycans in Glycoprotein Quality Control
- 37. Free Glycans as Signaling Molecules
- 38. Glycans in Development and Systemic Physiology
- 39. Bacterial and Viral Infections
- 40. Parasitic Infections
- 41. Genetic Disorders of Glycan Degradation
- 42. Genetic Disorders of Glycosylation
- 43. Glycans in Acquired Human Diseases
- 44. Glycosylation Changes in Cancer
- Part VI. Methods and Applications
- 45. Antibodies and Lectins in Glycan Analysis
- 46. Glycosylation Mutants of Cultured Cells
- 47. Structural Analysis of Glycans
- 48. Glycomics
- 49. Chemical and Enzymatic Synthesis of Glycans and Glycoconjugates
- 50. Chemical Tools for Inhibiting Glycosylation
- 51. Glycans in Biotechnology and the Pharmaceutical Industry
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Essentials of Glycobiology
