Essentials of Glycobiology

Glycobiology is an extension of modern molecular biology with roots in classical carbohydrate chemistry and biochemistry. The editors, in the preface to the first edition of this glycobiology textbook, believed that their work is a first of its kind. It was designed to create a textbook covering a complex and quickly evolving topic useful to both experts and novices wishing to learn more about the field.

It started with several faculty members who were teaching a graduate-level course on glycobiology at the University of California, San Diego. Add in a few new faculty members and conversations at a glycobiology conference and the table was set for the group of educators to create a basic textbook in glycobiology. Students were the initial editors, providing critiques of the text as part of their coursework.

The online glycobiology textbook has been compiled by a group of glycobiology educators and scholars under the direction of Dr. Ajit Varki and in collaboration with the National Library of Medicine/National Center for Biotechnology Information (NLM/NCBI).

Table of Contents for Essentials of Glycobiology Textbook

Part I. General Principles
1. Historical Background and Overview
2. Structural Basis of Glycan Diversity
3. Cellular Organization of Glycosylation
4. Glycosylation Precursors
5. Glycosyltransferases and Glycan-processing Enzymes
6. Biological Roles of Glycans
7. A Genomic View of Glycobiology
Part II. Structure and Biosynthesis
8. N-Glycans
9. O-GalNAc Glycans
10. Glycosphingolipids
11. Glycosylphosphatidylinositol Anchors
12. Other Classes of ER/Golgi-derived Glycans
13. Structures Common to Different Glycans
14. Sialic Acids
15. Hyaluronan
16. Proteoglycans and Sulfated Glycosaminoglycans
17. Nucleocytoplasmic Glycosylation
18. The O-GlcNAc Modification
Part III. Organismal Diversity
19. Evolution of Glycan Diversity
20. Eubacteria and Archaea
21. Fungi
22. Viridiplantae
23. Nematoda
24. Arthropoda
25. Deuterostomes
Part IV. Glycan-binding Proteins
26. Discovery and Classification of Glycan-Binding Proteins
27. Principles of Glycan Recognition
28. R-type Lectins
29. L-type Lectins
30. P-type Lectins
31. C-type Lectins
32. I-type Lectins
33. Galectins
34. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
35. Proteins that Bind Sulfated Glycosaminoglycans
Part V. Glycans in Physiology and Disease
36. Glycans in Glycoprotein Quality Control
37. Free Glycans as Signaling Molecules
38. Glycans in Development and Systemic Physiology
39. Bacterial and Viral Infections
40. Parasitic Infections
41. Genetic Disorders of Glycan Degradation
42. Genetic Disorders of Glycosylation
43. Glycans in Acquired Human Diseases
44. Glycosylation Changes in Cancer
Part VI. Methods and Applications
45. Antibodies and Lectins in Glycan Analysis
46. Glycosylation Mutants of Cultured Cells
47. Structural Analysis of Glycans
48. Glycomics
49. Chemical and Enzymatic Synthesis of Glycans and Glycoconjugates
50. Chemical Tools for Inhibiting Glycosylation
51. Glycans in Biotechnology and the Pharmaceutical Industry

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Essentials of Glycobiology

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